Fig. 3

Effect of SME on tyrosinase activity. Tyrosinase activity was measured using L-dopa as a substrate in the presence of SME (2.5–10 μg/mL), of 500 μM arbutin, or of 0.1% DMSO (control). The produced amount of dopachrome was determined by measuring the absorbance at 450 nm. The assay was performed in quadruplicate. Values represent the mean ± SEM. ^*p < 0.05, ^***p < 0.001 versus control by Dunnett’s multiple comparison test