Skip to main content

Table 1 The list of top upregulated and downregulated proteins after SDS treatment (25 μg/ml)

From: Proteomic characterization of HaCaT keratinocytes provides new insights into changes associated with SDS exposure

##

Accession

Description

Gene symbol

Peptides*

Fold change

GO—molecular function/biological process**

1

P09972

Fructose-bisphosphate aldolase C (ALDOC_HUMAN)

ALDOC

4

6.4

Glycolysis/gluconeogenesis

2

P04406

Glyceraldehyde-3-phosphate dehydrogenase (G3P_HUMAN)

GAPDH

18

5.9

Apoptosis, glycolysis

3

P07954

Fumarate hydratase, mitochondrial (FUMH_HUMAN)

FH

5

14.3

Tricarboxylic acid cycle

4

P06748

Nucleophosmin (NPM_HUMAN)

NPM1

5

5.7

Positive regulation of cell proliferation, Response to stress

5

P02533

Keratin, type I cytoskeletal 14 (K1C14_HUMAN)

KRT14

8

5.4

Keratinization, epidermis development

6

P09211

Glutathione S-transferase P (GSTP1_HUMAN)

GSTP1

10

5.2

Negative regulation of apoptotic process, detoxification of reactive oxygen species

7

P61981

14-3-3 protein gamma (1433G_HUMAN)

YWHAG

3

5.2

Regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

8

O75367

Core histone macro-H2A.1 (H2AY_HUMAN)

H2AFY

5

4.8

Regulation of response to oxidative stress, keratinocyte differentiation

9

P60953

Cell division control protein 42 homolog (CDC42_HUMAN)

CDC42

5

4.2

Differentiation

10

P13646

Keratin, type I cytoskeletal 13 (K1C13_HUMAN)

KRT13

17

3.0

Keratinization

11

P06733

Alpha-enolase (ENOA_HUMAN)

ENO1

21

3.0

Glycolysis/gluconeogenesis

12

P31930

Cytochrome b-c1 complex subunit 1, mitochondrial (QCR1_HUMAN)

UQCRC1

8

2.9

Electron transport, respiratory chain

13

P25705

ATP synthase subunit alpha, mitochondrial (ATPA_HUMAN)

ATP5A1

18

2.8

ATP synthesis, hydrogen ion transport, response to oxidative stress

14

P27797

Calreticulin (CALR_HUMAN)

CALR

7

2.6

Regulation of apoptotic process

15

P09758

Tumor-associated calcium signal transducer 2 (TACD2_HUMAN)

TACSTD2

8

2.2

Response to stimulus

16

P29590

Protein PML (PML_HUMAN)

PML

4

2.0

Negative regulation of cell growth and translation in response to oxidative stress

17

P99999

Cytochrome c (CYC_HUMAN)

CYCS

4

2.0

Apoptosis, electron transport, respiratory chain, transport

18

P31947

14-3-3 protein sigma (1433S_HUMAN)

SFN

14

1.9

Keratinocyte development

19

P00558

Phosphoglycerate kinase 1

PGK1

17

1.84

Glycolysis

20

P14550

Alcohol dehydrogenase [NADP(+)] (AK1A1_HUMAN)

AKR1A1

2

9.7

Plays a role in the activation of procarcino-gens and in the metabolism of various xenobiotics and drugs

21

P30048

Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3_HUMAN)

PRDX3

2

3.4

Detoxification of reactive oxygen species

22

P09758

ADP/ATP translocase 3 (ADT3_HUMAN)

SLC25A6

2

156.4

Apoptosis

23

P06744

Glucose-6-phosphate isomerase (G6PI_HUMAN)

GPI

11

1.7

Glycolysis/gluconeogenesis

24

P18669

Phosphoglycerate mutase 1 (PGAM1_HUMAN)

PGAM1

8

1.6

Glycolysis

25

Q9P258

Protein RCC2 (RCC2_HUMAN)

RCC2

4

− 1.8

Cell cycle, cell division, mitosis

26

O60437

Periplakin (PEPL_HUMAN)

PPL

5

− 2.0

Keratinization

27

P41252

Isoleucine-tRNA ligase, cytoplasmic

(SYIC_HUMAN)

IARS

3

− 2.0

Protein biosynthesis

28

O60716

Catenin delta-1(CTND1_HUMAN)

CTNND1

11

− 2.3

Cell adhesion

29

O14896

Interferon regulatory factor 6 (IRF6_HUMAN)

IRF6

3

− 2.3

Keratinocyte differentiation

30

Q9UIV8

Serpin B13 (SPB13_HUMAN)

SERPINB13

5

− 2.4

Regulates transcription of genes involved in differentiation of keratinocytes

31

Q9BS26

Endoplasmic reticulum resident protein 44 (ERP44_HUMAN)

ERP44

5

− 4.2

Stress response

32

O43809

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5_HUMAN)

NUDT21

2

− 4.8

Differentiation, mRNA processing

  1. *Peptide number automatically selected for identification and quantification by Progenesis LC software
  2. **Adapted from UniProt Knowledgebase