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Table 1 The list of top upregulated and downregulated proteins after SDS treatment (25 μg/ml)

From: Proteomic characterization of HaCaT keratinocytes provides new insights into changes associated with SDS exposure

##AccessionDescriptionGene symbolPeptides*Fold changeGO—molecular function/biological process**
1P09972Fructose-bisphosphate aldolase C (ALDOC_HUMAN)ALDOC46.4Glycolysis/gluconeogenesis
2P04406Glyceraldehyde-3-phosphate dehydrogenase (G3P_HUMAN)GAPDH185.9Apoptosis, glycolysis
3P07954Fumarate hydratase, mitochondrial (FUMH_HUMAN)FH514.3Tricarboxylic acid cycle
4P06748Nucleophosmin (NPM_HUMAN)NPM155.7Positive regulation of cell proliferation, Response to stress
5P02533Keratin, type I cytoskeletal 14 (K1C14_HUMAN)KRT1485.4Keratinization, epidermis development
6P09211Glutathione S-transferase P (GSTP1_HUMAN)GSTP1105.2Negative regulation of apoptotic process, detoxification of reactive oxygen species
7P6198114-3-3 protein gamma (1433G_HUMAN)YWHAG35.2Regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
8O75367Core histone macro-H2A.1 (H2AY_HUMAN)H2AFY54.8Regulation of response to oxidative stress, keratinocyte differentiation
9P60953Cell division control protein 42 homolog (CDC42_HUMAN)CDC4254.2Differentiation
10P13646Keratin, type I cytoskeletal 13 (K1C13_HUMAN)KRT13173.0Keratinization
11P06733Alpha-enolase (ENOA_HUMAN)ENO1213.0Glycolysis/gluconeogenesis
12P31930Cytochrome b-c1 complex subunit 1, mitochondrial (QCR1_HUMAN)UQCRC182.9Electron transport, respiratory chain
13P25705ATP synthase subunit alpha, mitochondrial (ATPA_HUMAN)ATP5A1182.8ATP synthesis, hydrogen ion transport, response to oxidative stress
14P27797Calreticulin (CALR_HUMAN)CALR72.6Regulation of apoptotic process
15P09758Tumor-associated calcium signal transducer 2 (TACD2_HUMAN)TACSTD282.2Response to stimulus
16P29590Protein PML (PML_HUMAN)PML42.0Negative regulation of cell growth and translation in response to oxidative stress
17P99999Cytochrome c (CYC_HUMAN)CYCS42.0Apoptosis, electron transport, respiratory chain, transport
18P3194714-3-3 protein sigma (1433S_HUMAN)SFN141.9Keratinocyte development
19P00558Phosphoglycerate kinase 1PGK1171.84Glycolysis
20P14550Alcohol dehydrogenase [NADP(+)] (AK1A1_HUMAN)AKR1A129.7Plays a role in the activation of procarcino-gens and in the metabolism of various xenobiotics and drugs
21P30048Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3_HUMAN)PRDX323.4Detoxification of reactive oxygen species
22P09758ADP/ATP translocase 3 (ADT3_HUMAN)SLC25A62156.4Apoptosis
23P06744Glucose-6-phosphate isomerase (G6PI_HUMAN)GPI111.7Glycolysis/gluconeogenesis
24P18669Phosphoglycerate mutase 1 (PGAM1_HUMAN)PGAM181.6Glycolysis
25Q9P258Protein RCC2 (RCC2_HUMAN)RCC24− 1.8Cell cycle, cell division, mitosis
26O60437Periplakin (PEPL_HUMAN)PPL5− 2.0Keratinization
27P41252Isoleucine-tRNA ligase, cytoplasmic
(SYIC_HUMAN)
IARS3− 2.0Protein biosynthesis
28O60716Catenin delta-1(CTND1_HUMAN)CTNND111− 2.3Cell adhesion
29O14896Interferon regulatory factor 6 (IRF6_HUMAN)IRF63− 2.3Keratinocyte differentiation
30Q9UIV8Serpin B13 (SPB13_HUMAN)SERPINB135− 2.4Regulates transcription of genes involved in differentiation of keratinocytes
31Q9BS26Endoplasmic reticulum resident protein 44 (ERP44_HUMAN)ERP445− 4.2Stress response
32O43809Cleavage and polyadenylation specificity factor subunit 5 (CPSF5_HUMAN)NUDT212− 4.8Differentiation, mRNA processing
  1. *Peptide number automatically selected for identification and quantification by Progenesis LC software
  2. **Adapted from UniProt Knowledgebase