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Table 1 Description of the investigational studies on oxidative stress gene polymorphisms in vitiligo workers and healthy controls

From: Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

Single nucleotide polymorphism (SNP) Genotype Ethnicity Number of subjects Type of study Findings Reference
GST-M1
rs366631
GST-T1
rs17856199
Positive/null** Egyptian 122 cases
200 controls
Experimental Subjects with GSTM1 null/heterozygous GSTT1 positive show a 2.97 OR protection from having generalized vitiligo compared with patients. Aly et al. 2018
Egyptian 101 cases
101 controls
Experimental GST-M1-null and GST-M1/GST-T1 double-null genotype represent a risk factor in women with vitiligo. Bassiouny and Khorshied 2012
Iraq 100 cases
90 controls
Experimental GST-M1- and GST-T1-null genotype show a significant association with vitiligo disorder. Jalood et al. 2016
Korean
Chinese
Mediterranean
Egyptian
1258 cases1573 controls Meta-analysis GST-M1- and GST-T1-null genotypes are significantly associated with vitiligo. Park HK et al. 2016
Han Chinese 749 cases
763 controls
Experimental Homozygous deletion of GST-T1 subjects have higher vitiligo risk than that of GST-M1 although both genotypes have a predisposition to vitiligo. Liu et al. 2009
Italian
Egyptian
Korean
Chinese
1358 cases
1673 controls
Meta-analysis GST-M1-null polymorphism significantly associated with vitiligo risk in East Asian but not with Mediterranean subjects.
GST-T1-null polymorphism correlated with vitiligo risk in Mediterranean but not with East Asian subjects.
Lu et al. 2014
NRF2- 653 A/G
rs35652124
AA/AG/GG Han Chinese 1136 cases
1200 controls
Experimental Decreased risk of vitiligo associated with the NRF2 rs35652124 variant G allele (GG+GA genotype) while no evident risk is associated with NRF2 rs6721961 variant (AA). Song P et al. 2016
NRF2 -617 C/A
rs6721961 formerly -650 C/A
CC/CA/AA Han Chinese 300 cases
300 controls
Experimental A -650 allele is higher in patients than in controls and may be a risk factor associated with the development of vitiligo. Guan et al. 2008
HO-1 rs2071746
-413 A/T
AA/AT/TT Han Chinese 1136 cases
1200 controls
Experimental No evidence of correlation between allele and genotype frequencies of HO-1 rs2071746 A/T) and the disease. Song P et al. 2016
HO-1 (GT)n repeats
S>L
GT lenght variability Taiwanese 367 cases
420 controls
Experimental Reduced risk is associated to the presence of short (GT)n repeats in the HO-1 gene promoter when exposed to environmental toxicants (no data available on vitiligo). Wu et al. 2010
CAT (389 C/T) rs769217
Asp389Asp Ex 9
CC/CT/TT US/Canadian 235 cases
177 controls
Experimental Excess of heterozygosis (CT) in vitiligo subjects. Casp et al. 2002
CAT (389 C/T) rs769217
Asp389Asp Ex 9
CC/CT/TT Caucasian 166 cases
169 controls
Experimental CAT gene C/T SNP associated with vitiligo susceptibility with the C/T genotype being significantly more frequent among vitiligo patients than healthy controls. Gavalas et al. 2006
CAT (389 C/T) rs769217
Asp389Asp Ex 9
CC/CT/TT US/Canadian/UK
Korean
Gujarati Indian
645 cases
689 controls
Meta-analysis The authors suggest CT+TT genotype increases the susceptibility risk of vitiligo in the analysed populations. Lv et al. 2011
CAT (389 C/T) rs769217 Asp389Asp Ex 9 CC/CT/TT Egyptian 89 cases
90 controls
Experimental Lack of association between CAT 389 C/T and vitiligo susceptibility in Egyptian patients. Mehaney et al. 2014
CAT -89A/T (rs7943316) CC/CT/TT Gujarati Indian 126 cases
143 controls
Experimental No association between CAT gene 389C/T polymorphism and vitiligo susceptibility. Shajil et al. 2007
CAT (C/T) rs769217
Asp389Asp Ex 9
CC/CT/TT
AA/AT7TT
Korean 118 cases
200 controls
Experimental The catalase gene polymorphism (rs769217 and rs7943316) may contribute to the susceptibility of vitiligo in Korean population, although susceptibility difference among ethnic groups may be due to a change in the allele frequency. Park HH et al. 2006
CAT (C/T) rs769217
Asp389Asp Ex 9
CAT (A/T) rs7943316
CC/CT/TT
AA/AT/TT
UK 103 cases
107 ethnic controls
Experimental Absence of association between CAT gene -89A>T and 389C>T polymorphism and vitiligo susceptibility. Akbas et al. 2013
SOD1 35A/C rs2234694 AA/AC/CC Turkish 101 cases
99 controls
Experimental SOD1 35 A/C was similar in vitiligo patients and controls showing absence of significant difference between AA and AC genotypes. Tuna et al. 2017
SOD2 A16V (C/T) rs4880 CC/CT/TT Significant difference between cases and controls in the SOD2 Ala16Val (C/T) polymorphism with increased risk in the TT genotype.
SOD1
Ile40Thr (C/T) rs1804450
Vall82Val (T/C) rs11556619
Asn87Ser (A/G) rs11556620
Asn140Asn (C/T) rs1804449
CC/CT/TT
TT/TC/CC
AA/AG/GG
CC/CT/TT
Gujarati Indian 950 cases
1650 controls
Experimental No association between SOD1 SNPs and vitiligo. Laddha et al. 2013a, b
SOD2
Leu84Phe (C/T) rs11575993)
Thr58Ile (C/T) rs35289490) Val16Ala (T/C) rs4880)
Ile82Thr (T/C ) rs1141718)
CC/CT/TT
CC/CT/TT
TT/TC/CC
TT/TC/CC
Association between SOD1 rs35289490 and rs11575993 with vitiligo.
Absence of significant association of SOD2 rs4880 with vitiligo, although the C allele is prelavent in subjects with active vitiligo in comparison to patients with stable vitiligo.
SOD3
Arg213Gly (C/G) rs8192291
Ala40Thr (G/A) rs2536512
CC/CG/GG
GG/GA/AA
SOD3 rs8192291 SOD3 polymorphism was significantly associated with vitiligo susceptibility. The G allele was prevalent in patients compared to controls.
  1. For each polymorphism, the alternating nucleotides reported in brackets are coincident with those found on the DNA forward strand
  2. The name of each gene polymorphism is listed by using its common abbreviation, e.g., GST, NRF2, SOD
  3. The rs code is an accession number used in databases to refer to specific and unique SNPs
  4. **GST-M1 and GST-T1 null means the absence of both polymorphic genes