Single nucleotide polymorphism (SNP) | Genotype | Ethnicity | Number of subjects | Type of study | Findings | Reference |
---|---|---|---|---|---|---|
GST-M1 rs366631 GST-T1 rs17856199 | Positive/null** | Egyptian | 122 cases 200 controls | Experimental | Subjects with GSTM1 null/heterozygous GSTT1 positive show a 2.97 OR protection from having generalized vitiligo compared with patients. | Aly et al. 2018 |
Egyptian | 101 cases 101 controls | Experimental | GST-M1-null and GST-M1/GST-T1 double-null genotype represent a risk factor in women with vitiligo. | Bassiouny and Khorshied 2012 | ||
Iraq | 100 cases 90 controls | Experimental | GST-M1- and GST-T1-null genotype show a significant association with vitiligo disorder. | Jalood et al. 2016 | ||
Korean Chinese Mediterranean Egyptian | 1258 cases1573 controls | Meta-analysis | GST-M1- and GST-T1-null genotypes are significantly associated with vitiligo. | Park HK et al. 2016 | ||
Han Chinese | 749 cases 763 controls | Experimental | Homozygous deletion of GST-T1 subjects have higher vitiligo risk than that of GST-M1 although both genotypes have a predisposition to vitiligo. | Liu et al. 2009 | ||
Italian Egyptian Korean Chinese | 1358 cases 1673 controls | Meta-analysis | GST-M1-null polymorphism significantly associated with vitiligo risk in East Asian but not with Mediterranean subjects. GST-T1-null polymorphism correlated with vitiligo risk in Mediterranean but not with East Asian subjects. | Lu et al. 2014 | ||
NRF2- 653 A/G rs35652124 | AA/AG/GG | Han Chinese | 1136 cases 1200 controls | Experimental | Decreased risk of vitiligo associated with the NRF2 rs35652124 variant G allele (GG+GA genotype) while no evident risk is associated with NRF2 rs6721961 variant (AA). | Song P et al. 2016 |
NRF2 -617 C/A rs6721961 formerly -650 C/A | CC/CA/AA | Han Chinese | 300 cases 300 controls | Experimental | A -650 allele is higher in patients than in controls and may be a risk factor associated with the development of vitiligo. | Guan et al. 2008 |
HO-1 rs2071746 -413 A/T | AA/AT/TT | Han Chinese | 1136 cases 1200 controls | Experimental | No evidence of correlation between allele and genotype frequencies of HO-1 rs2071746 A/T) and the disease. | Song P et al. 2016 |
HO-1 (GT)n repeats S>L | GT lenght variability | Taiwanese | 367 cases 420 controls | Experimental | Reduced risk is associated to the presence of short (GT)n repeats in the HO-1 gene promoter when exposed to environmental toxicants (no data available on vitiligo). | Wu et al. 2010 |
CAT (389 C/T) rs769217 Asp389Asp Ex 9 | CC/CT/TT | US/Canadian | 235 cases 177 controls | Experimental | Excess of heterozygosis (CT) in vitiligo subjects. | Casp et al. 2002 |
CAT (389 C/T) rs769217 Asp389Asp Ex 9 | CC/CT/TT | Caucasian | 166 cases 169 controls | Experimental | CAT gene C/T SNP associated with vitiligo susceptibility with the C/T genotype being significantly more frequent among vitiligo patients than healthy controls. | Gavalas et al. 2006 |
CAT (389 C/T) rs769217 Asp389Asp Ex 9 | CC/CT/TT | US/Canadian/UK Korean Gujarati Indian | 645 cases 689 controls | Meta-analysis | The authors suggest CT+TT genotype increases the susceptibility risk of vitiligo in the analysed populations. | Lv et al. 2011 |
CAT (389 C/T) rs769217 Asp389Asp Ex 9 | CC/CT/TT | Egyptian | 89 cases 90 controls | Experimental | Lack of association between CAT 389 C/T and vitiligo susceptibility in Egyptian patients. | Mehaney et al. 2014 |
CAT -89A/T (rs7943316) | CC/CT/TT | Gujarati Indian | 126 cases 143 controls | Experimental | No association between CAT gene 389C/T polymorphism and vitiligo susceptibility. | Shajil et al. 2007 |
CAT (C/T) rs769217 Asp389Asp Ex 9 | CC/CT/TT AA/AT7TT | Korean | 118 cases 200 controls | Experimental | The catalase gene polymorphism (rs769217 and rs7943316) may contribute to the susceptibility of vitiligo in Korean population, although susceptibility difference among ethnic groups may be due to a change in the allele frequency. | Park HH et al. 2006 |
CAT (C/T) rs769217 Asp389Asp Ex 9 CAT (A/T) rs7943316 | CC/CT/TT AA/AT/TT | UK | 103 cases 107 ethnic controls | Experimental | Absence of association between CAT gene -89A>T and 389C>T polymorphism and vitiligo susceptibility. | Akbas et al. 2013 |
SOD1 35A/C rs2234694 | AA/AC/CC | Turkish | 101 cases 99 controls | Experimental | SOD1 35 A/C was similar in vitiligo patients and controls showing absence of significant difference between AA and AC genotypes. | Tuna et al. 2017 |
SOD2 A16V (C/T) rs4880 | CC/CT/TT | Significant difference between cases and controls in the SOD2 Ala16Val (C/T) polymorphism with increased risk in the TT genotype. | ||||
SOD1 Ile40Thr (C/T) rs1804450 Vall82Val (T/C) rs11556619 Asn87Ser (A/G) rs11556620 Asn140Asn (C/T) rs1804449 | CC/CT/TT TT/TC/CC AA/AG/GG CC/CT/TT | Gujarati Indian | 950 cases 1650 controls | Experimental | No association between SOD1 SNPs and vitiligo. | |
SOD2 Leu84Phe (C/T) rs11575993) Thr58Ile (C/T) rs35289490) Val16Ala (T/C) rs4880) Ile82Thr (T/C ) rs1141718) | CC/CT/TT CC/CT/TT TT/TC/CC TT/TC/CC | Association between SOD1 rs35289490 and rs11575993 with vitiligo. Absence of significant association of SOD2 rs4880 with vitiligo, although the C allele is prelavent in subjects with active vitiligo in comparison to patients with stable vitiligo. | ||||
SOD3 Arg213Gly (C/G) rs8192291 Ala40Thr (G/A) rs2536512 | CC/CG/GG GG/GA/AA | SOD3 rs8192291 SOD3 polymorphism was significantly associated with vitiligo susceptibility. The G allele was prevalent in patients compared to controls. |