TY - JOUR AU - Lim, Kye Hwa AU - Kim, Gyu Ri PY - 2018 DA - 2018/11/01 TI - Inhibitory effect of naringenin on LPS-induced skin senescence by SIRT1 regulation in HDFs JO - Biomedical Dermatology SP - 26 VL - 2 IS - 1 AB - This study aims to investigate the ability of naringenin to regulate the expression of nuclear factor-кB, the upper gene of lipopolysaccharide-induced SIRT1; regulate signal transduction in the extracellular matrix, which plays an important role in the dermis; and alter the matrix metalloproteinase 1 and matrix metalloproteinase 3 gene expression, therefore having suppressing effect on skin cell senescence and deoxyribonucleic acid protection and cell protection effects and confirm naringenin’s potential as an important cosmetic ingredient. SN - 2398-8460 UR - https://doi.org/10.1186/s41702-018-0035-6 DO - 10.1186/s41702-018-0035-6 ID - Lim2018 ER -