From: Exploring vitiligo susceptibility and management: a brief review
Gene | Locus | Protein | Role |
---|---|---|---|
BACH2 | 6q15 | BTB domain and CNC homolog 2 | B cell regulator |
BTNL2 | 6p21.32 | Butyrophilin-like 2 | T cell regulator |
CASP7 | 10q25.3 | Caspase 7 | Apoptosis |
CAT | 11p13 | Catalase | Oxidative stress regulator |
CCR6 | 6q27 | C-C motif chemokine receptor 6 | B cell, T cell and dendritic cell regulator |
CD44 | 11p13 | CD44 antigen | T cell regulator |
CD80 | 3q13.33 | T-lymphocyte activation antigen CD80 | T cell priming by B cells, T cells and dendritic cells |
CLNK | 4p16.1 | Cytokine-dependent hematopoietic cell linker | Positive regulator of mast cells |
C1QTNF6 | 22q12.3 | Complement C1q tumor necrosis factor-related protein 6 | Immune response-induced apoptosis |
CTLA4 | 2q33.2 | Cytotoxic T-lymphocyte protein 4 | T cell inhibition |
CXCR5 | 11q23.3 | C-X-C motif chemokine receptor 5 | B cell activity |
FGFR1OP | 6q27 | Fibroblast growth factor receptor 1 oncogene partner | Cell growth and proliferation |
FOXP3 | Xp11.23 | Forkhead box protein P1 | T cell activity and development |
GSTP1 | 11q13.2 | Glutathione S-transferase Pi 1 | Oxidative stress regulator |
GZMB | 14q12 | Granzyme B | Cytotoxic T lymphocyte-mediated death |
HLA-A, HLA-B and HLA-C | 6p22.1 | Human leukocyte antigen A, B and C | Peptide antigen presentation |
HLA-DQB1 and HLA-DRB1 | 6p21.32 | Human leukocyte antigen DQB1 and DRB1 | Peptide antigen presentation |
IFIH1 | 2q24.2 | Interferon-induced helicase C domain containing protein 1 | Innate immune activity |
IFNAR1 | 21q22.11 | Interferon alpha and beta receptor subunit 1 | T cell signaling |
IKZF4 | 12q13.2 | Zinc finger protein Eos | T cell regulator |
IL2RA | 10p15.1 | Interleukin-2 receptor subunit alpha | Interleukin 2-dependent T cell activation |
LTA | 6p21.33 | Lymphotoxin alpha | Immune response-induced apoptosis |
MC1R | 16q24.3 | Melanocortin 1 receptor | Melanogenesis regulator |
MTHFR | 1p36.22 | Methylenetetrahydrofolate reductase | Oxidative stress regulator |
NLRP1 | 17p13.2 | NLR family pyrin domain containing 1 | Innate immune Activity |
OCA2 | 15q12-13-1 | P protein | Melanosomal transporter |
PMEL | 12q13.2 | Premelanosome protein | Melanosomes regulator |
PTPN22 | 1p13.2 | Tyrosine-protein phosphatase non-receptor type 22 | T cell signaling |
RERE | 1p36.23 | Arginine-glutamic acid dipeptide repeats protein | Lymphoid co-repressor |
SH2B3 | 12q24.12 | SH2B adaptor protein 3 | T cell signaling |
SLA | 8q24.22 | Src-like adaptor | T cell signaling |
SOD2 and SOD3 | 6q25.3, 4p15.2 | Superoxide dismutase 2 and 3 | Oxidative stress regulator |
TICAM1 | 19p13.3 | Toll-like receptor adaptor molecule 1 | Innate immune activity |
TLR2 and TLR4 | 4q31.3, 9q33.1 | Toll-like receptor 2 and 4 | Innate immune activity |
TNF | 6p21.33 | Tumor necrosis factor | Cell proliferation, differentiation and apoptosis |
TYR | 11q14.3 | Tyrosinase | Melanogenesis regulator |
UBASH3A | 21q22.3 | Ubiquitin associated and SH3 domain containing A | T cell signaling |
ZMIM1 | 10q22.3 | Zinc finger MIZ-type containing 1 | Transcriptional co-activator |