Fig. 1

Effects of A. muricata L. extracts on melanin production and cell viability in B16F10 melanoma cells. a Effects of A. muricata extracts on cytotoxicity in B16F10 melanoma cells. MTT assays were used to determine cytotoxic activities and appropriate concentration ranges in B16F10 cells. In these experiments, survival rates were 90% or higher after treatments with A. muricata L. extracts at 60 μg/mL or less. b Effects of A. muricata extracts on melanin contents in B16F10 melanoma cells; *p < 0.05. Melanin contents of mouse melanoma cells were determined after treatment with A. muricata L. extracts at 60 μg/mL. In these experiments, α-MSH-induced melanogenesis was reduced to 24.42% in cells treated with A. muricata L. extracts compared to those treated with α-MSH only