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Fig. 1 | Biomedical Dermatology

Fig. 1

From: Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application

Fig. 1

Schematic comparison between iPSC technology and direct conversion to generate DA neurons from skin fibroblasts in vitro for biomedical application. IPSC geneartion requires a forced expression/induction of reprogramming factors or small molecules. Several differentiation protocols provide robust yields of DA neurons highly resembling DA neuron characteristics with effective recovery of animal PD model. Direct induced dopamine neurons are derived from skin fibroblasts, which minimizes undesired differentiation potential and risks for teratoma formation

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Biomedical Dermatology

ISSN: 2398-8460

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